▎ 摘　　要

A novel hybrid of graphene oxide (GO) and hypocrellin B (HB) was prepared using a simple noncovalent method. An efficient loading of HB on GO as high as 2 mg/mg was obtained. Mechanism analysis indicated that the pi-pi stacking interaction is the dominant driving force in the noncovalent interaction between HB and GO. Irradiation of HB and GO hybrid (HB-GO) results in efficient generation of singlet oxygen (O-1(2)). In vitro studies have demonstrated the active uptake of HB-GO into the cytosol of tumor cells. Significant damage to such impregnated tumor cells was observed upon irradiation. (C) 2012 Elsevier Ltd. All rights reserved.