• 文献标题:   Synthesis of merit-combined antimony tetroxide nanoflowers/reduced graphene oxide to synergistically boost real-time detection of nitric oxide released from living cells for high sensitivity
  • 文献类型:   Article
  • 作  者:   DENG XR, ZOU Z, ZHANG YH, GAO JC, LIANG TT, LU ZS, LI CM
  • 作者关键词:   antimony oxide, nanomaterial, electrochemical sensor, in situ, nitric oxide
  • 出版物名称:   JOURNAL OF COLLOID INTERFACE SCIENCE
  • ISSN:   0021-9797 EI 1095-7103
  • 通讯作者地址:  
  • 被引频次:   12
  • DOI:   10.1016/j.jcis.2020.07.076
  • 出版年:   2021

▎ 摘  要

Nitric oxide (NO) is an important bio-regulatory and signaling molecule associated with various physiological and pathophysiological pathways, but its sensitive real-time detection is still very challenging due to the low concentration, large diffusivity and fast decay in biological samples. Here an antimony tetroxide (Sb2O4) nanoflowers/reduced graphene oxide (rGO) nanocomposite is synthesized via a facile and eco-friendly solvothermal method to merit-combine highly electroactive Sb2O4 nanoflowers with large surficial rGO component for a strong synergistic effect on oxidation of NO. Results demonstrate that the Sb2O4/rGO-based sensor has a low detection limit, high sensitivity, excellent selectivity and fast response for NO detection. The real-time detected NO released from living cells showed significant difference between normal and tumor cells. The Sb2O4 nanoflowers/rGO nanocomposite sensor holds a great promise for important applications in biomedical research fields and clinical diagnosis. (C) 2020 Published by Elsevier Inc.