• 文献标题:   Synthesis of beta-Amino Ketones using graphene oxide: a benign carbonaceous acid catalyst for Mannich reaction
  • 文献类型:   Article
  • 作  者:   GANESAN NS, SURESH P
  • 作者关键词:   graphene oxide, mannich reaction, multicomponent synthesi, betaamino ketone, bronsted acid catalyst
  • 出版物名称:   RESEARCH ON CHEMICAL INTERMEDIATES
  • ISSN:   0922-6168 EI 1568-5675
  • 通讯作者地址:  
  • 被引频次:   3
  • DOI:   10.1007/s11164-020-04324-3 EA JAN 2021
  • 出版年:   2021

▎ 摘  要

Simple and easily preparable graphene oxide (GO) is used as a straightforward carbocatalyst for the synthesis of beta-amino ketones via a 3-component Mannich reaction under mild condition. The native GO is acting as a carbonaceous solid Bronsted acid catalyst without any special functionalization, yielding a spectrum of beta-amino ketones under metal-free conditions. The present catalytic method offers a benign and simple procedure without any hazardous workup, and chromatographic purification resulted in an excellent yield of beta-amino ketones. The catalyst has shown good sustainability up to 6 consecutive catalytic cycles without any significant loss in its activity. The stability of the recovered catalyst is proved by analytical techniques such as FT-IR, PXRD, SEM, and TEM. This mild solid-acid catalyst offers an alternative and sustainable approach to get synthetically essential beta-amino ketones under greener conditions. [GRAPHICS]