• 文献标题:   Interaction of graphene oxide with human serum albumin and its mechanism
  • 文献类型:   Article
  • 作  者:   DING ZJ, MA HW, CHEN YY
  • 作者关键词:  
  • 出版物名称:   RSC ADVANCES
  • ISSN:   2046-2069
  • 通讯作者地址:   Chinese Acad Sci
  • 被引频次:   25
  • DOI:   10.1039/c4ra09613d
  • 出版年:   2014

▎ 摘  要

Human serum albumin (HSA) is chosen to investigate the interaction of graphene oxide-based nanosheets (GONS) with plasma proteins in terms of binding affinity, action mechanism, conformational change and function loss. We show that GONS inhibit HSA function via two routes: blocking protein active sites, or destroying protein structure.