▎ 摘　　要

An interpenetrating network (IPN) strategy has been widely facilitated to construct strong and tough hydrogels, but most of the efforts have been focused on organic/organic networks. Herein, aqueous dispersible 2,2'-(ethylenedioxy)-diethanethiol (EDDET) cross-linked graphene oxide (E-cGO) skeleton was in situ incorporated into a PVA matrix, resulting in novel inorganic/organic IPN hydrogels with super mechanical and chondrocyte cell-adhesion properties. The unique interpenetrating structure and hydrogen bonding were demonstrated to play critical roles in enhancing the compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated as being biocompatible, which make the E-cGO/PVA hydrogels promising candidate biomaterials for load-bearing biotissue substitution.