• 文献标题:   Graphene oxide and adenosine triphosphate as a source for functionalized carbon dots with applications in pH-triggered drug delivery and cell imaging
  • 文献类型:   Article
  • 作  者:   ZHANG M, ZHOU NL, YUAN P, SU YT, SHAO MN, CHI C
  • 作者关键词:  
  • 出版物名称:   RSC ADVANCES
  • ISSN:   2046-2069
  • 通讯作者地址:   Nanjing Normal Univ
  • 被引频次:   13
  • DOI:   10.1039/c6ra27887f
  • 出版年:   2017

▎ 摘  要

A folate-functionalized carbon dot-based nanocarrier system has been successfully synthesized for cancer cell targeted drug delivery. We hydrothermally synthesized blue photoluminescent N, P-CDs using adenosine triphosphate and graphene oxide as the startingmaterials. The particle size of the N, P-CDswas ca. 3.8 nm. An anticancer drug, doxorubicin (DOX), was grafted onto the carbon dots via electrostatic interactions, and a more specific anticancer agent (DOX/N, P-CDs) was obtained. The DOX/N, P-CDs were characterized by H-NMR, C-NMR and UV-vis analysis. In addition, the DOX/N, P-CDs showed a pH-dependent release and were easily absorbed by cells. When compared to DOX, DOX/N, P-CDs nanoparticles exhibited the same cytotoxicity towards human cervical cancer cells (HeLa cells) and human pulmonary adenocarcinoma cells (A549 cells). Hemolysis test results indicated that DOX/N, P-CDs were safe for blood-contact applications and were suitable for intravenous administration. Owing to their intrinsic biocompatibility, N, P-CDs can be used for cell imaging and drug delivery with excellent targeting property.