• 文献标题:   Highly fluorescent and morphology-controllable graphene quantum dots-chitosan hybrid xerogels for in vivo imaging and pH-sensitive drug carrier
  • 文献类型:   Article
  • 作  者:   LV OY, TAO YX, QIN Y, CHEN CX, PAN Y, DENG LH, LIU L, KONG Y
  • 作者关键词:   graphene quantum dot, chitosan, xerogel, in vivo imagine, drug delivery
  • 出版物名称:   MATERIALS SCIENCE ENGINEERING CMATERIALS FOR BIOLOGICAL APPLICATIONS
  • ISSN:   0928-4931 EI 1873-0191
  • 通讯作者地址:   Changzhou Univ
  • 被引频次:   28
  • DOI:   10.1016/j.msec.2016.05.031
  • 出版年:   2016

▎ 摘  要

Highly fluorescent graphene quantum dots (GQDs)-chitosan (CS) hybrid xerogels (GQDs-CS) were facilely synthesized, and the morphology of GQDs-CS was controllable by varying the content of GQDs in the xerogel. The GQDs-CS exhibited a porous and three-dimensional (3D) network structure when the content of GQDs reached 43% (wt%) in the xerogel, which was beneficial for drug loading and sustained release. The as-prepared GQDs-CS could also be applied for in vivo imaging since it showed strong blue, green and red luminescence under excitation of varying wavelengths. Moreover, the pH-induced protonation/deprotonation of the -NH2 groups on CS chains can result in a pH-dependent drug delivery behavior of the GQDs-CS hybrid xerbgel. (C) 2016 Elsevier B.V. All rights reserved.