• 文献标题:   Preparation, photoluminescence properties and application for in vivo tumor imaging of curcumin derivative-functionalized graphene oxide composite
  • 文献类型:   Article
  • 作  者:   XU GY, WANG JF, SI GF, WANG MH, CHENG HL, CHEN B, ZHOU SS
  • 作者关键词:   curcumin derivative, functionalized graphene oxide, optical property, biological imaging
  • 出版物名称:   DYES PIGMENTS
  • ISSN:   0143-7208 EI 1873-3743
  • 通讯作者地址:   Anhui Univ
  • 被引频次:   4
  • DOI:   10.1016/j.dyepig.2017.02.046
  • 出版年:   2017

▎ 摘  要

Curcumin derivative-functionalized graphene oxide (CUDE-f-GO) composite was synthesized via direct polycondensation reaction in a binary phase system. The composite was characterized by MIR, H-1 NMR, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), thermal gravimetric analysis (TGA) and atomic force microscopy (AFM). Digital camera and transmission electron microscopy (TEM) images showed that the composite had better dispersion in phosphate buffer solution (PBS) than graphene oxide (GO). The photophysical experiments revealed that the photoluminescence (PL) properties were significantly enhanced when curcumin derivative (CUDE) was covalently grafted on the surfaces of GO. The in vitro and in vivo bioimaging results showed that CUDE-f-GO composite was an ideal optical material for biological imaging because of its good photostability, low cytotoxicity, bright bioimaging and excellent tumor targeting ability. (C) 2017 Elsevier Ltd. All rights reserved.