• 文献标题:   Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration
  • 文献类型:   Article
  • 作  者:   JUNG HS, CHOI YJ, JEONG J, LEE Y, HWANG B, JANG J, SHIM JH, KIM YS, CHOI HS, OH SH, LEE CS, CHO DW, HAHN SK
  • 作者关键词:  
  • 出版物名称:   RSC ADVANCES
  • ISSN:   2046-2069
  • 通讯作者地址:   Pohang Univ Sci Technol POSTECH
  • 被引频次:   15
  • DOI:   10.1039/c6ra03905g
  • 出版年:   2016

▎ 摘  要

Titanium (Ti) is one of the representative biocompatible metallic materials which has been widely exploited for various implants and bone replacements. Here, commercially pure Ti (CP Ti) was surface-modified with reduced graphene oxide (RGO) for accelerated bone regeneration and osseointegration. Nanoscale RGO coating on CP Ti was clearly confirmed by SEM, AFM, EDS, XPS, HR-TEM and EELS. In addition, pre-osteoblast cells cultured on RGO-CP Ti showed higher cell viability and cell attachment than those on CP Ti. After confirmation of the drug loading capability of RGO-CP Ti, osteogenic dexamethasone loaded RGO-CP Ti (Dex/RGO-CP Ti) was implanted on calvarial bone defects in rats. Synchrotron X-ray imaging successfully visualized more effective bone regeneration on Dex/RGO-CP Ti than CP Ti and RGO-CP Ti after 8 weeks.