▎ 摘　　要

Field-effect transistors (FET) using low-dimensional materials has attracted attention for detection of DNA hybridization. Here, we proposed a photocurrent-modulated FET sensor, where the I-photocurrent(gate) + I-photocurrent(DNA) dramatically enhance the response signal, I-current, compared to a tradi-tional FET sensor. The proposed sensor successfully detects DNA signals with a limit of detection (LOD) down to attomolar concentrations that is nearly 100x lower than a traditional FET sensor. The sensing mechanism is postulated and discussed. The results suggest that photo-coupled modulation opens new avenues for further development of the FET in biosensing applications. (C) 2021 Elsevier Ltd. All rights reserved.