• 文献标题:   Black hemostatic sponge based on facile prepared cross-linked graphene
  • 文献类型:   Article
  • 作  者:   QUAN KC, LI GF, LUAN D, YUAN QP, TAO L, WANG X
  • 作者关键词:   graphene, cgs, hemostatic sponge, hemostasi, clotting
  • 出版物名称:   COLLOIDS SURFACES BBIOINTERFACES
  • ISSN:   0927-7765 EI 1873-4367
  • 通讯作者地址:   Beijing Univ Chem Technol
  • 被引频次:   27
  • DOI:   10.1016/j.colsurfb.2015.04.067
  • 出版年:   2015

▎ 摘  要

In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40 ms) to form a blood cell layer and promotes subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity, and long shelf life of the portable black sponge, the CGS has great potential for trauma treatment. (c) 2015 Elsevier B.V. All rights reserved.