▎ 摘　　要

Highly aligned ultrafine fibers of graphene/poly(L-lactic acid)(Gr/PLLA) composite were prepared for studying the synergistic effect of fiber orientation degree and Gr incorporation on nerve cell growth and differentiation, from which nerve conduits by reeling. heating the aligned Gr/PLLA fibers were fabricated for potential neural tissue engineering applications. The results showed that the Gr/PLLA fibers made by stable jet electrospinning (SJES) had higher degree of fiber alignment. Incorporation of Gr improved the thermal and mechanical properties of the PLLA fibers. Increasing the Gr content and fiber orientation degree gave rise to increased adhesion number and elongation percentage of the Schwann cells (SCs). All the fiber scaffolds could promote SCs to proliferate well and cells growth reached the best state at 96 h, indicating appropriate cytocom. patibility of the Gr/PLLA fibers. In addition, it was found the aligned Gr/PLLA fibers also promoted the neural differentiation of PC12 cells. The nerve conduits with inner diameter of 2 mm made of Gr/PLLA fibers showed good axial fiber orientation degree and pressure. resistance ability, and could promote cell growth directionally.