▎ 摘　　要

The purpose of this paper is to determine the therapeutic contribution of graphene oxide (GO) to photo/sonosensitizers through photo-physicochemical and sono-photochemical studies for the first time. In this way, new zinc (II) phthalocyanine bearing 3-chloro-4-fluorophenoxy (2) was synthesized; and then, its graphene oxide (GO)-based composites were prepared by noncovalently coating ZnPc (2) on the graphene oxide surface. The photo-activity of these materials was compared and discussed in terms of their potential ability to be used in photosensitizer in photodynamic therapy (PDT) and sono-photody-namic therapy (SPDT). In these application areas, graphene oxide can serve as photosensitizer carrier, while ZnPc (2) can be acting as PDT/SPDT agent. Therefore, phthalocyanine composites containing different percentages of graphene oxide by weight (wt% GO) were prepared. SEM (scanning electron microscopy) results supported the interaction between GO and ZnPc (2). In the sono-photochemical study (SPDT), both ZnPc (2) and its composites gave very higher F? values than the photochemical study (PDT). The sono-photochemical values were found to be 0.976 for 0 wt% GO, 0.961 for 0.25 wt% GO, 0.917 for 0.50 wt% GO, 0.910 for 1 wt% GO, 0.901 for 3 wt% GO, 0.890 for 5 wt% GO and 0.942 for 10 wt% GO, respectively. To the best of our knowledge, this is the first study of the use of phthalocyanines with GO by sonophotochemically as potential photosensitizers for sono-photodynamic therapy (SPDT) applications. According to obtained results, ZnPc (2) and its composites could be promise as good photosensitizers for both PDT and SPDT due to their very high singlet oxygen generation in both the photochemical study (PDT) and the sono-photochemical study (SPDT).