• 文献标题:   Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering: in vivo behavior assessment
  • 文献类型:   Article
  • 作  者:   IVANOSKADACIKJ A, BOGOEVAGACEVA G, KRUMME A, TARASOVA E, SCALERA C, STOJKOVSKI V, GJORGOSKI I, RISTOSKI T
  • 作者关键词:   biodegradable scaffold, biocompatibility, biodegradable polyurethane, electrospinning
  • 出版物名称:   INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS POLYMERIC BIOMATERIALS
  • ISSN:   0091-4037 EI 1563-535X
  • 通讯作者地址:   Acad Sci Arts Republ North Macedonia
  • 被引频次:   2
  • DOI:   10.1080/00914037.2019.1655754 EA AUG 2019
  • 出版年:   2020

▎ 摘  要

In this work, 3D porous electrospun scaffolds based on DegraPol (R) (DP), a polyester urethane, with different concentrations of graphene oxide (GO) (0.0-2.0 wt%) were obtained. In order to produce scaffolds with increased porosity, solutions of DP and GO were co-electrospun with polyethylene oxide (PEO), which was subsequently removed. The electrospinning resulted in the formation of porous and fibrous scaffolds with superior elasticity. The colloidal Ag was successfully used as a novel method of scaffold sterilization. The results of the in vivo analysis showed scaffold degradation, absence of an inflammatory process and penetration of tissue cells in the scaffold.