▎ 摘　　要

A novel electrochemical sensor was prepared by electrodeposition of copper nanoparticles ( CuNPs) on a zinc oxide/graphene ( ZnO/GO) modified ITO electrode and applied to the determination of kanamycin sulfate ( KANA). The morphology of material and modified electrodes was characterized by scanning electron microscope. With optimization of measurement conditions systematically, the result showed that the electrochemical response of KANA on CuNPs/ZnO/GO/ITO electrode was the largest when the number of electrodeposition scanning circles were 40 in 0. 15 mol/L PBS ( pH = 6. 5) solution. The mechanism of electrode reaction of KANA involved one electron process, and the effective area (0. 482 cm(2)) of CuNPs/ ZnO/GO/ITO electrode was 2. 42 times as large as that of a bare ITO electrode. Moreover, the linear response range for determination of KANA was 0. 99-30. 6 mu mol/L, the linear equation was I-pc = -5. 183c-4. 544x10(-6) with the detection limit of 0. 31 mu mol/L, and the recoveries of standard addition experiments were 97. 8% - 103. 6%. The sensor shows good stability and reproducibility, and can be used to detect kanamycin sulfate in the drug samples.