• 文献标题:   Graphene-electrode array for brain map remodeling of the cortical surface
  • 文献类型:   Article
  • 作  者:   LEE M, LEE S, KIM J, LIM J, LEE J, MASRI S, BAO SW, YANG SG, AHN JH, YANG S
  • 作者关键词:  
  • 出版物名称:   NPG ASIA MATERIALS
  • ISSN:   1884-4049 EI 1884-4057
  • 通讯作者地址:  
  • 被引频次:   8
  • DOI:   10.1038/s41427-021-00334-8
  • 出版年:   2021

▎ 摘  要

Cortical maps, which are indicative of cognitive status, are shaped by the organism's experience. Previous mapping tools, such as penetrating electrodes and imaging techniques, are limited in their ability to be used to assess high-resolution brain maps largely owing to their invasiveness and poor spatiotemporal resolution, respectively. In this study, we developed a flexible graphene-based multichannel electrode array for electrocorticography (ECoG) recording, which enabled us to assess cortical maps in a time- and labor-efficient manner. The flexible electrode array, formed by chemical vapor deposition (CVD)-grown graphene, provided low impedance and electrical noise because a good interface between the graphene and brain tissue was created, which improved the detectability of neural signals. Furthermore, cortical map remodeling was induced upon electrical stimulation at the cortical surface through a subset of graphene spots. This result demonstrated the macroscale plasticity of cortical maps, suggesting perceptual enhancement via electrical rehabilitation at the cortical surface.