▎ 摘 要
Designing catalysts that achieve the rates and selectivities of natural enzymes is a long-standing goal in synthetic chemistry. Herein, the carboxyl-controlled-graphene oxide supported 3-aminopropyl-triethoxysilane (GO(n)-APTS) heterogeneous catalyts like the class I aldolases with -NH2 and phenolic -OH groups were developed and applied in aldol reaction. The results demonstrate that the amount of -NH2 groups and phenolic -OH groups play important roles of activity and selectivity, respectively. The most efficiency catalyst GO(8)-APTS shows an excellent conversion of over 90% with a high aldol product selectivity of about 89%. Furthermore, the catalyst can be easily recovered and reused at least 5 times without significant loss of the reactivity. [GRAPHICS]