▎ 摘　　要

The designing and preparation of a safe drug carrier with sustained and controlled poorly water-soluble drug release ability is valuable in medicine. By considering this aim, magnetic graphene oxide (MG) was prepared through the co-precipitation o f the Fe3+ and Fe2+ ions on the graphene oxide (GO) surface. The prepared MG was coated with mesoporous silica (MG@mSiO(2)). Ibuprofen (IBU) as a poorly water-soluble drug was loaded into the MG@mSiO(2) nanosystem and MG@mSiO(2)-IBU was obtained. MG@mSiO(2)-IBU showed the burst drug release behavior and released about 86 % of IBU in the first 2 h. To overcome this burst release of IBU, carboxymethyl cellulose (CMC) was used as a coating agent for the encapsulation of MG@mSiO(2)-IBU. Drug release studies showed that CMC-coated MG@mSiO2-IBU (CMC/MG@mSO(2)-IBU) sustainably released the IBU in 8 h with a first-order kinetic model. MG@mSiO(2) and CMC/MG@mSiO(2)-IBU were characterized by using various techniques. VSM analysis displayed the superparamagnetic properties for the CMC/MG@mSiO(2)-IBU. Based on the MTT and drug release investigation results the prepared CMC/MG@mSiO(2)-IBU bio-nanocomposite could be proposed potentially as a safe carrier with controlled release of the poorly water-soluble IBU drug.