▎ 摘　　要

Since its discovery in 2004, the new frontier materials graphene and its derivatives have attracted a great deal of attention on the fields of new batteries, sensors, new energy and biomedicine, due to their unique electrical, optical and mechanical properties. Specifically, it has been developed rapidly in the biomedical field. The good biocompatibility has endowed graphene and its derivatives great prospects for their biological applications. In order to realize the in vivo application of graphene materials and improve the safety of the environment and life system, it is crucial to consider and study on the biodegradation behaviors of graphene. The research on biodegradation of graphene currently mainly focuses on the enzymatic degradation. The degradation behaviors can be tuned by the modification via a series of methods, such as heterogeneous atom doping and surface functionalization, etc. The progress of biodegradation of graphene and their derivatives, especially the enzymatic degradation and their biomedical applications is discussed. The important basis and guidance to further promote the in vivo study of graphene materials will be provided.