• 文献标题:   Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide
  • 文献类型:   Article
  • 作  者:   HE LJ, SARKAR S, BARRAS A, BOUKHERROUB R, SZUNERITS S, MANDLER D
  • 作者关键词:  
  • 出版物名称:   CHEMICAL COMMUNICATIONS
  • ISSN:   1359-7345 EI 1364-548X
  • 通讯作者地址:   Hebrew Univ Jerusalem
  • 被引频次:   15
  • DOI:   10.1039/c7cc00381a
  • 出版年:   2017

▎ 摘  要

The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.