▎ 摘　　要

Electro-analytical methods are interested in the interaction of electricity and chemistry, calculating quantities of electricity mainly current, potential, charges and their association with chemical properties. This usage for scientific purposes of electrical measurements has found a wide variety of uses, particularly in industrial quality management, environmental pollution management, and biomedical research. Theophylline (THP) is one of the phosphodiesterase inhibiting drugs used in the treatment of asthmatic disorders. High dosage implements some adverse effect on the health. Thus, in the present study, we have prepared the electrode by drop casting graphene oxide ? nanoclay matrix on the glassy carbon electrode surface (GO-NC/GCE), for the quantification of THP. The electrochemical study of THP was done by using cyclic voltammetry and square wave voltammetry techniques. Voltammograms reveals that, higher electro-oxidation peak current of THP at modified electrode suggesting the effective modification of the electrode. From the pH study, it?s found that the THP has undergone an oxidation mechanism involving the same number of electrons and protons. The sweep rate effect revealed that two number of electrons were involved in the diffusion controlled electrode mechanism. A wide range of linearity was found for GO-NC/GCE, 3.0 x 10-8?5.0 x 10-4 M with LOD value 3.12 x 10-9 M. Excipients and Metal ion interference study shows the selectivity and analysis of THP in pharmaceutical drug and spiked urine samples gives the real time applications of modified electrode. We have discovered that the modified electrode shows remarkable detection and good recovery value.