• 文献标题:   Novel chitosan-graphene quantum dots composite for therapeutic delivery and tracking through enzymatic stimuli response
  • 文献类型:   Article
  • 作  者:   KUMARA BN, SHAMBHU R, PRABHU A, PRASAD KS
  • 作者关键词:   chitosan, drug delivery, graphene quantum dot, lysozyme, photoluminescence
  • 出版物名称:   CARBOHYDRATE POLYMERS
  • ISSN:   0144-8617 EI 1879-1344
  • 通讯作者地址:  
  • 被引频次:   3
  • DOI:   10.1016/j.carbpol.2022.119426 EA APR 2022
  • 出版年:   2022

▎ 摘  要

The designing of highly efficient and biocompatible nanocomposites with multifunctional delivery and tracking characteristics is noteworthy for clinical and therapeutic applications. Herein, we report the proof-of-concept for the delivery of anti-glaucoma drug, latanoprost (LP) under an enzymatic stimulus, lysozyme (Lyz) with novel chitosan (CS) graphene quantum dots (GQD) nanocomposite via reverse switching photoluminescence (PL) phenomenon. The LP caged CS-GQDs nanocomposite was well characterized through extensive spectral, morphological, band-gap, particle size, and zeta potential studies along with cytotoxicity assays. The regaining of PL not only confirmed LP delivery, but also facilitated intercellular tracking through in vitro bio-imaging against human corneal epithelial (HCE) cells. The AO/EB staining and biocompatibility assays further proved excellent cell viability of > 80%. The successfully delivered LP protected HCE cells from oxidative injury induced by 800 mu M hydrogen peroxide (H2O2). These findings justify further utility of novel CS-GQDs caged drug nanocomposite for preclinical investigations.