▎ 摘　　要

The separation of racemic drugs remains significance and challenge for pharmaceutical production. Recently, chiral drugs permeation separation based on membrane is a promising technology with advantages of energy efficient, continuous operation and cost-effectiveness. Herein, ethylenediamine-beta-cyclodextrin (EDA-beta-CD) mixed matrix membranes (EDA-beta-CD MMMs) and EDA-beta-CD modified graphene oxide thin-film nanocomposite membranes (GO/EDA-beta-CD TFNMs) were fabricated via precipitation phase inversion and interfacial polymerization process, respectively. The corresponding membrane structure and GO nanosheets were characterized by SEM, TEM, ATR FT-IR, EA. Subsequently, the water flux, BSA rejection and stability of the membranes were studied. Moreover, enantioseparation performances of GO/EDA-beta-CD TFNMs and EDA-beta-CD MMMs toward (DL)tryptophan (Trp) and (RS)-propranolol (Prop) were examined. Results showed that the GO/EDA-beta-CD TFNMs exhibited extraordinary enantioselectivity, which remained high percent enantiomeric excess (ee.%) of Trp (100.00%) and Prop (75.34%). GO nanosheets with a multilayer structure and an interlayer spacing not only provided bonding site of EDA-beta-CD but also improved permeation flux of the membrane. Finally, molecular docking technology was used to study the separation mechanism of the membranes. These findings demonstrate that GO/EDA-beta-CD TFNMs might possess possibilities of high permeability and high enantioselectivity for chiral drugs separation.