• 文献标题:   Graphene as multifunctional delivery platform in cancer therapy
  • 文献类型:   Review
  • 作  者:   NEJABAT M, CHARBGOO F, RAMEZANI M
  • 作者关键词:   graphene, graphene oxide, drug delivery, gene delivery, targeting
  • 出版物名称:   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
  • ISSN:   1549-3296 EI 1552-4965
  • 通讯作者地址:   Mashhad Univ Med Sci
  • 被引频次:   10
  • DOI:   10.1002/jbm.a.36080
  • 出版年:   2017

▎ 摘  要

The biomedical applications of graphene-based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene-based materials in introducing an effective cargo delivery system for cancer therapy. Different approaches for reducing cytotoxic impacts of graphene oxide and production of biocompatible delivery platform were also reviewed. (C) 2017 Wiley Periodicals, Inc.