▎ 摘　　要

Significant progress is achieved for the utilization of graphene quantum dots as enzyme mimics in various biomedical fields recently. Although promising, the biocatalytic performance is far from satisfactory. Here, the rational design and synthesis of specific oxygenated groups enriched graphene quantum dots (o-GQDs) via a facile oxidation reflux route is reported. These well-prepared o-GQDs with uniform size exhibit an ultrahigh peroxidase-like activity in a wide range of pH values, and their superior performance is verified by using glucose detection as a typical model. Compared with classical nanozymes, these o-GQDs show multiple times higher enzymatic activity. It is believed that the super facile synthesis strategy can greatly facilitate the practical use of o-GQDs as enzyme mimics in the future.