• 文献标题:   Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements
  • 文献类型:   Article
  • 作  者:   KIREEV D, SEYOCK S, LEWEN J, MAYBECK V, WOLFRUM B, OFFENHAUSSER A
  • 作者关键词:   extracellular recording, gmea, graphene, neuron
  • 出版物名称:   ADVANCED HEALTHCARE MATERIALS
  • ISSN:   2192-2640 EI 2192-2659
  • 通讯作者地址:   Forschungszentrum Julich
  • 被引频次:   8
  • DOI:   10.1002/adhm.201601433
  • 出版年:   2017

▎ 摘  要

Graphene multielectrode arrays (GMEAs) presented in this work are used for cardio and neuronal extracellular recordings. The advantages of the graphene as a part of the multielectrode arrays are numerous: from a general flexibility and biocompatibility to the unique electronic properties of graphene. The devices used for extensive in vitro studies of a cardiac-like cell line and cortical neuronal networks show excellent ability to extracellularly detect action potentials with signal to noise ratios in the range of 45 +/- 22 for HL-1 cells and 48 +/- 26 for spontaneous bursting/spiking neuronal activity. Complex neuronal bursting activity patterns as well as a variety of characteristic shapes of HL-1 action potentials are recorded with the GMEAs. This paper illustrates that the potential applications of the GMEAs in biological and medical research are still numerous and diverse.