• 文献标题:   Graphene quantum dots based MnFe2O4@SiO2 magnetic nanostructure as a pH-sensitive fluorescence resonance energy transfer (FRET) system to enhance the anticancer effect of the drug
  • 文献类型:   Article
  • 作  者:   NEJAD ZK, KHANDAR AA, KHATAMIAN M
  • 作者关键词:   cell cycle, daunorubicin dau, apoptosi, fluorescence resonance energy transfer fret
  • 出版物名称:   INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • ISSN:   0378-5173 EI 1873-3476
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1016/j.ijpharm.2022.122254 EA OCT 2022
  • 出版年:   2022

▎ 摘  要

Among the various methods of targeted drug delivery, magnetic nanoparticles been considered for a long time due to local drug delivery, reduction of side effects, and controlled drug release. In this work, fluorescence resonance energy transfer (FRET) system MnFe2O4@SiO2@ graphene quantum dots /DAU with 28.02 emu g-1 magnetism was prepared as pH-sensitive nanoplatform to enhance the anti-cancer effect of daunorubicin (DAU) drug (in the obtained FRET system, DAU act as acceptor molecule and graphene quantum dots act as donor molecule). The efficiency of the drug loaded on the nanoplatform in vitro is 78 %. DAU drug release from nanoplatform at pHs of 7.4 and 5.5 during 48 h is 21 % and 60 %, respectively. Release sensitive to pH facilitates the application of prepared nanoplatform for DAU delivery. The results of MTT-assay and annexin V-FITC/PI show that MnFe2O4@SiO2@ graphene quantum dots /DAU induces cell apoptosis by inhibiting the growth of more than 95 % of MCF-7 cells. Also, according to the results, it was found that MnFe2O4@SiO2@ graphene quantum dots /DAU can inhibit 66.65 % cell cycle in the sub-G1 phase. Therefore, due to the anti-cancer activity of MnFe2O4@SiO2@ graphene quantum dots /DAU, this biological nanoscale can be considered a candidate for drug delivery.