• 文献标题:   Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides
  • 文献类型:   Article
  • 作  者:   RODRIGUEZ CE, PALACIOS J, FAJARDO I, URDIALES JL, LE GUEVEL X, LOZANO J, SANCHEZJIMENEZ F
  • 作者关键词:   graphene, malditof/tof, phosphorylated peptide
  • 出版物名称:   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • ISSN:   1044-0305 EI 1879-1123
  • 通讯作者地址:   Univ Malaga
  • 被引频次:   5
  • DOI:   10.1007/s13361-015-1299-3
  • 出版年:   2016

▎ 摘  要

This is the first study where graphene is used as a MALDI adjuvant in combination with the traditional matrix alpha-cyano-4-hydroxycinnamic acid (CHCA) to improve the signal intensity of peptide samples. Use of this amended matrix not only leads to increased signals but also to a higher number of peaks detected in complex samples. Additionally, the use of graphene has a stabilizing effect that can also be exploited to improve the detection of easily cleavable molecules.