• 文献标题:   Shear-thinning and self-healing chitosan-graphene oxide hydrogel for hemostasis and wound healing
  • 文献类型:   Article
  • 作  者:   FENG WJ, WANG ZK
  • 作者关键词:   chitosan, graphene oxide, injectable self healing hydrogel, hemostasi, wound healing
  • 出版物名称:   CARBOHYDRATE POLYMERS
  • ISSN:   0144-8617 EI 1879-1344
  • 通讯作者地址:  
  • 被引频次:   23
  • DOI:   10.1016/j.carbpol.2022.119824 EA JUL 2022
  • 出版年:   2022

▎ 摘  要

Hydrogels with injectability, self-healing ability and adhesiveness have great potential for hemostasis and full -thickness skin wound repair, which are usually fabricated by multistep chemical synthesis and the use of organic solvents and catalyst. Herein, we report an injectable and self-healing hydrogel facilely prepared through one-pot heating of chitosan and graphene oxide mixture solution, without any pollutant and waste generated. The dynamic reversible breakage and recombination of noncovalent bonds between chitosan and graphene oxide endows the hydrogel injectability and self-healing ability. In addition, the mechanical and rheological properties of the hydrogels can be controlled by varying the dosage of graphene oxide. Meanwhile, hydrogels exhibited good adhesiveness and hemocompatibility. Finally, in vivo experiments in a rat liver bleeding model and full -thickness skin defect model verified the outstanding hemostatic and wound healing capability of the hydro -gels, indicating the promising future for use as wound dressing.