▎ 摘　　要

In this study, a novel biosensor was produced from a carbonized gold (Au)/graphene (G) hybrid nanowire fabricated on a disposable screen-printed carbon electrode (SPCE) in order to amplify signals. The processes of carbonization and electrospinning were merged in order to determine dopamine (DA) in a selective and sensitive manner when it is present in uric acid (UA) or ascorbic acid (AA). In order to assess the nature of the surface morphology and the physical product properties, transmission electron microscopy, scanning electron microscopy, and X-ray diffraction were employed prior to and following the carbonization step. The modified electrode (CPAN-Au/G) in [Fe(CN)(6)](3-/4-) and DA was examined using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) in order to establish the electrochemical behavior. The findings from this test revealed that the modified electrode was capable of selectively identifying DA in 0.1 M PBS at pH 7.4 when other substances were present to provide interference. This process did not require the use of an anionic surfactant to serve as the discriminating agent. From the analysis of the DPV current, a linear dependence upon DA concentrations became apparent, in the range of 0.001-60 M when the detection limit was 0.8 nM (S/N = 3) and sensitivity was 1.4351 A cm(-2). DA quantities in human serum could be effectively detected using the CPAN-Au/G electrode, and the modified electrode raises considerable expectations for application as a high-potential electrode. This would permit the determination of DA in a selective and sensitive manner while achieving sensor stability over the long term.