• 文献标题:   The Efficient Regeneration of Corneal Nerves via Tunable Transmembrane Signaling Channels Using a Transparent Graphene-Based Corneal Stimulation Electrode
  • 文献类型:   Article
  • 作  者:   ZHENG Z, LIN MM, LU WC, HUANG PP, ZHENG YR, ZHANG XC, YAN L, WANG W, LAWSON T, SHI BY, CHEN SA, LIU Y
  • 作者关键词:   electrical stimulation, nitrogendoped graphene, corneal nerve, nerve regeneration, lasik
  • 出版物名称:   ADVANCED HEALTHCARE MATERIALS
  • ISSN:   2192-2640 EI 2192-2659
  • 通讯作者地址:  
  • 被引频次:   3
  • DOI:   10.1002/adhm.202101667 EA FEB 2022
  • 出版年:   2022

▎ 摘  要

The efficient regeneration of corneal nerves is of limited success in the field of ophthalmology. This work reports the use of a non-invasive electrical stimulation technique that uses a transparent graphene-based corneal stimulation electrode and that can achieve efficient regeneration of corneal nerves. The corneal stimulation electrode is prepared using electroactive nitrogen-containing conducting polymers such as polyaniline functionalized graphene (PAG). This composite can carry a high capacitive current. It can be used to tune transmembrane signaling pathways including calcium channels and the MAPK signaling pathway. Tuning can lead to the efficient regeneration of corneal damaged nerves after the surgery of laser in-situ keratomileusis (LASIK). The composite and its application reported have the potential to provide a new way to treat nerve-related injuries.