▎ 摘　　要

Developing a rapid and sensitive photo-electrochemical (PEC) sensing platform for glucose detection is highly desirable. Herein, a visible light-driven PEC enzyme biosensor for sensitive detection of glucose was proposed, employing reduced graphene oxide/titania (TiO2) nanotubes (RGO/TNTs) as photoactive materials and glucose oxidase (GOD) as the identification element. The RGO/TNTs composites were synthesized via a facile hydrothermal process. Notably, the unique nanostructure system significantly increases the absorption in the visible region and effectively separates the photo-generated electron-hole pairs, which is essential for promoting the PEC activity. In the presence of dissolved oxygen, the GOD immobilized on the modified electrode could specifically catalyze the electro-oxidation of glucose to produce H2O2, resulting in an increase of photocurrent intensity. Based on the variation of the photocurrent response, the constructed PEC enzyme biosensor exhibited high sensitivity with a wide linear range from 10(-2) to 10 mM and a low detection limit of 5.0 mu M. Meanwhile, the potential applicability of the PEC enzyme biosensor was evaluated by detecting glucose in human serum samples, and satisfactory results were obtained.