▎ 摘　　要

In cancer treatment, combination therapy has been considered as an attractive strategy to lower side effects and enhance therapeutic efficacy. Herein, we fabricated a kind of reduced-graphene-oxide-based drug delivery system for combination therapy, in which reduced graphene oxide (rGO) as photothermal agent and drug carrier was modified by PEGylated (PEG, polyethylene glycol) tetrahydroxyphenyl porphyrin (THPPEG) via a pi-pi stacking interaction. The obtained rGO/THPPEG not only showed good biocompatibility and water solubility, but also realized the combination of photothermal therapy with photodynamic therapy. The rGO/THPPEG nanoparticles with stable nanosize were demonstrated by Fourier transform infrared spectroscopy, Raman spectroscopy, TGA, X-ray photoelectron spectroscopy, TEM images and dynamic light scattering. To verify the feasibility of delivering drugs, doxorubicin (DOX) was chosen to prepare rGO/THPPEG/DOX, realizing synergetic photothermal/photodynamic/chemotherapy. The data of in vitro experiments indicated that rGO/THPPEG/DOX could obviously inhibit tumour growth, outlining the significant potential for future cancer treatment. (c) 2021 Society of Industrial Chemistry.