• 文献标题:   Poly(Lactic Acid) Fine Fibers Containing a Low Content of Superhydrophilic Multi-Walled Carbon Nanotube Graphene Oxide Hybrid as Scaffolds for Biological Applications
  • 文献类型:   Article
  • 作  者:   ANDRADE PO, GRINET MAVM, COSTA MM, SANTO AME, MARCIANO FR, LOBO AO
  • 作者关键词:   carbon nanotube, graphene oxide, poly lactic acid, rotary jet spinning, superhydrophilic
  • 出版物名称:   MACROMOLECULAR MATERIALS ENGINEERING
  • ISSN:   1438-7492 EI 1439-2054
  • 通讯作者地址:   Univ Brasil
  • 被引频次:   2
  • DOI:   10.1002/mame.201800317
  • 出版年:   2018

▎ 摘  要

Herein, polylactic acid containing two different concentrations of superhydrophilic multiwalled carbon nanotube graphene oxide hybrid (MWCNT-GO, 0.5 wt% and 5 wt%) is rotary-jet spun. The morphological, thermal, and surface wettability properties are then evaluated. Biological properties, including cytotoxicity, fibroblast cell adhesion, and the overall bioactive effect, are also investigated. It is demonstrated that the thermal behavior is affected by the presence of MWCNT-GO, as well as the crystallinity. The addition of MWCNT-GO, even in small amounts, reduces the wettability property of the fibers, making them more hydrophobic. However, biological tests with these fibers show no cytotoxic effect in all fiber sample groups, even when MWCNT-GO concentration is increased. Therefore, nano-structured, porous, and biocompatible polymeric scaffolds are obtained, with a high surface area and with notable potential for tissue engineering applications.