▎ 摘　　要

In this study, the electrochemical behavior of sulpiride (SUL) was examined deeply by using pyrolytic graphite electrode modified with graphene oxide (GO) and beta-cyclodextrin (beta-CD). The developed nanosensor indicated considerable impact by significantly increasing the signal of SUL compared with the bare electrode. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) methods were utilized to investigate the SUL electrochemical analysis in aqueous solutions. Under optimum experimental conditions, calibration plot for SUL with a limit of detection of 2.83 x 10(-9) M was obtained at accumulation time of the 30 s using square wave adsorptive stripping voltammetric technique (AdSSWV) in the range of 1.0 x 10(-7) to 5.0 x 10(-5) M. The effects of accumulation potential, accumulation time, pH, scan rate, electrolyte, and interfering agents were studied to obtain the intensive peak signal of the analyte. The presented method is validated and successfully performed for the determination of the SUL tablet and capsule. The fabricated nanosensor was carried out for the detection of SUL in the urine. Excellent recoveries among 104.37, 103.82, and 101.95% were obtained for tablet and capsule forms and urine analysis.