▎ 摘　　要

A beta oligomers have been widely accepted as significant biomarkers for Alzheimer's disease (AD) detection, monitoring, and therapy since they are highly correlated with AD development. In this work, an electrochemical array-based sensing platform was successfully built using a group of functionalized graphene with different physicochemical features. Since the electro-insulated A beta peptide species severely interfered with the electron transport on the electrode surface, the presence of A beta led to a significant change in the electrochemical impedance signal. The resulting variety of the impedance was then classified and processed by linear discrimi-nant analysis. The constructed sensing platform can discriminate different A beta forms, the mixture of various A beta forms, and different ratios of A beta 42 to A beta 40 with 100% accuracy by only the combination of dual probes. Furthermore, it also exhibited excellent performance for screening A beta inhibitors and metal chelators. The strategy utilizes the infinitesimal general discrepancy instead of specific biomarker recognition, exhibiting the advantage of no requirement to know the exact information about the specific ligand and receptor in advance, which is promising to be widened for the other biosensing detection fields.