▎ 摘　　要

2D graphene oxide (GO) with large surface area, multivalent structure can easily bind single-stranded DNA/RNA (aptamers) through hydrophobic/pi-stacking interactions, whereas aptamers having small size, excellent chemical stability and low immunogenicity bind to their targets with high affinity and specificity. GO-aptamer conjugate materials synthesized by integrating aptamers with GO can thus provide a better alternative to antibody-based strategies for cancer diagnostic and therapy. Moreover, GO's excellent fluorescence quenching properties can be utilized to develop efficient fluorescence-sensing platforms. In this review, recent advances in GO-aptamer conjugate materials for the detection of major cancer biomarkers have been discussed.