▎ 摘　　要

Graphene is a widely used material as a therapeutic agent (drug) carrier due to its low toxicity, high surface area, specific flake-shape, 2-dimensional structure and geometry. In order to evaluate the efficiency of drug delivery improved by using graphene oxide as a drug carrier, drug release experiment using Cytochrome-C (Cyto- C), a model drug, was carried out. First of all, different ratios of Cyto-C were combined with 100 mg GO to investigate the best drug-loading efficiency so that the best loading ratio was confirmed with Cyto-C:GO of 1:2. Alginate hydrogel (Alg hydrogel) and Alginate-Graphene oxide hydrogel (Alg-GO hydrogel) were fabricated by cross-linking in 0.1 M CaCl2 solution. Characterization of the hydrogels was confirmed by Fourier transform infrared (FT-IR) and scanning electron microscope (SEM) analysis. The drug efficiency by the ratio of graphene oxide to Cyto-C was compared by ultraviolet visible spectrophotometer (UV-VIS). The difference in drug release behavior in hydrogels was confrimed by drug release test. The Alg-GO hydrogel exhibited slow and steady release compared to that of alginate hydrogel as control. In this study, we demonstrated that applying graphene oxide as a drug carrier affects in control of drug release behavior.