▎ 摘　　要

The motive of the present investigation was to establish a novel, hybrid multifunctional lipid-coated graphene oxide mesoporous silica nanocomposite (GO-MSN) for controlled delivery of Rizatriptan Benzoate (RiB). The lipid coating helps to achieve a longer circulation time of the fabricated carrier for targeted delivery of RiB. The modified Hummers method with slight modification gives a uniform sheet of GO, subsequently sol-gel approach use to synthesized mesoporous silica for the preparation of nanocomposite. The in-vitro RiB release from RiB-GO-MSN and lipid decorated GO-MSN was found to be 70.74% and 63.45% respectively. The lipid coating retards the release of RiB around 8 h. The entrapment efficiency of RiB-MSN and GO-MSN were found to be 48.17% and 62.29% respectively. In the presence of GO, RiB entrapment increases as RiB may entrap within inter and intra spacing of GO. The present investigation oversee, simple methodology adopted for synthesis of GO-MSN can effectively deliver RiB towards brain for the management of migraine.