▎ 摘　　要

A simple, inexpensive, highly sensitive, selective novel electrochemical method was developed for selective determination of the anti-hepatitis C dalactasavir (DAC) using a carbon paste electrode modified with manganese oxide nanoparticles-reduced graphene oxide (MnO2-rGO). MnO2-rGO was characterized by different methods. The fabricated electrochemical sensor based on MnO2-rGO was electrochemically characterized using cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy. Such developed platform, best worked at pH 6.0 in Britton-Robinson buffer solution, shows linear electrocatalytic activity in the concentration range from 1.0 to 200.0nM DAC, with a low detection limit of 1.25 x 10(-)(10) M and excellent selectivity, repeatability and reproducibility with RSD 97.8% to -102.0%. A voltammetric method using the square wave voltammetry (SWV) was utilized as a sensitive method for the determination of very low concentrations of DAC. The development of this new kind of DAC sensor can offer a novel tool for point-of-care applications in biomedicine.