• 文献标题:   Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics
  • 文献类型:   Review
  • 作  者:   SIVAKUMAR PM, ISLAMI M, ZARRABI A, KHOSRAVI A, PEIMANFARD S
  • 作者关键词:   cancer, graphene nanoassemblie, drug delivery, polymer, theranostics agent, polymer moietie
  • 出版物名称:   ANTICANCER AGENTS IN MEDICINAL CHEMISTRY
  • ISSN:   1871-5206 EI 1875-5992
  • 通讯作者地址:   Sabanci Univ Nanotechnol Res Applicat Ctr SUNUM
  • 被引频次:   0
  • DOI:   10.2174/1871520619666191028112258
  • 出版年:   2020

▎ 摘  要

Background and objective: Graphene-based nanomaterials have received increasing attention due to their unique physical-chemical properties including two-dimensional planar structure, large surface area, chemical and mechanical stability, superconductivity and good biocompatibility. On the other hand, graphene-based nanomaterials have been explored as theranostics agents, the combination of therapeutics and diagnostics. In recent years, grafting hydrophilic polymer moieties have been introduced as an efficient approach to improve the properties of graphene-based nanomaterials and obtain new nanoassemblies for cancer therapy. Methods and results: This review would illustrate biodistribution, cellular uptake and toxicity of polymer-graphene nanoassemblies and summarize part of successes achieved in cancer treatment using such nanoassemblies. Conclusion: The observations showed successful targeting functionality of the polymer-GO conjugations and demonstrated a reduction of the side effects of anti-cancer drugs for normal tissues.