• 文献标题:   Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
  • 文献类型:   Article
  • 作  者:   SALADINO ML, MARKOWSKA M, CARMONE C, CANCEMI P, ALDUINA R, PRESENTATO A, SCAFFARO R, BIALY D, HASIAK M, HRENIAK D, WAWRZYNSKA M
  • 作者关键词:   graphene oxide nanocomposite, carboxymethyl cellulose, biocompatibility, medical device
  • 出版物名称:   MATERIALS
  • ISSN:  
  • 通讯作者地址:   Univ Palermo
  • 被引频次:   4
  • DOI:   10.3390/ma13081980
  • 出版年:   2020

▎ 摘  要

Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.