• 文献标题:   Vitamin C-reduced graphene oxide improves the performance and stability of multimodal neural microelectrodes
  • 文献类型:   Article
  • 作  者:   MURPHY BB, APOLLO NV, UNEGBU P, POSEY T, RODRIGUEZPEREZ N, HENDRICKS Q, CIMINO F, RICHARDSON AG, VITALE F
  • 作者关键词:  
  • 出版物名称:   ISCIENCE
  • ISSN:  
  • 通讯作者地址:  
  • 被引频次:   1
  • DOI:   10.1016/j.isci.2022.104652 EA JUL 2022
  • 出版年:   2022

▎ 摘  要

Nanocarbons are often employed as coatings for neural electrodes to enhance surface area. However, processing and integrating them into microfabrication flows requires complex and harmful chemical and heating conditions. This article presents a safe, scalable, cost-effective method to produce reduced graphene oxide (rGO) coatings using vitamin C (VC) as the reducing agent. We spray coat GO + VC mixtures onto target substrates, and then heat samples for 15 min at 150 degrees C. The resulting rGO films have conductivities of similar to 44 S cm(-1), and are easily integrated into an ad hoc microfabrication flow. The rGO/Au microelectrodes show similar to 8x ower impedance and similar to 400x higher capacitance than bare Au, resulting in significantly enhanced charge storage and injection capacity. We subsequently use rGO/Au arrays to detect dopamine in vitro, and to map cortical activity intraoperatively over rat whisker barrel cortex, demonstrating that conductive VC-rGO coatings improve the performance and stability of multimodal microelectrodes for different applications.