• 文献标题:   Biological activity of electrochemically synthesized silver doped polyvinyl alcohol/graphene composite hydrogel discs for biomedical applications
  • 文献类型:   Article
  • 作  者:   ABUDABBUS MM, JEVREMOVIC I, JANKOVIC A, PERICGRUJIC A, MATIC I, VUKASINOVICSEKULIC M, HUI D, RHEE KY, MISKOVICSTANKOVIC V
  • 作者关键词:   polymermatrix composites pmcs, chemical propertie, electron microscopy, nondestructive testing
  • 出版物名称:   COMPOSITES PART BENGINEERING
  • ISSN:   1359-8368 EI 1879-1069
  • 通讯作者地址:   Univ Belgrade
  • 被引频次:   18
  • DOI:   10.1016/j.compositesb.2016.08.024
  • 出版年:   2016

▎ 摘  要

Silver/poly(vinyl alcohol), Ag/PVA, and silver/poly(vinyl alcohol)/graphene, Ag/PVA/Gr, composite hydrogel discs were produced by freezing/thawing, followed by electrochemical reduction of Ag+ ions inside respective matrices, at constant voltage in specially designed electrochemical cell. Raman, FT-IR and FE-SEM characterized interactions between PVA, graphene and silver nanoparticles. Ag/PVA and Ag/PVA/Gr discs classified as non-cytotoxic towards peripheral blood mononuclear cells (PBMC) according to MTT cytotoxicity test, while exhibiting antibacterial activity against Staphylococcus aureus and Escherichia coli. The slow silver release and high remaining silver content of similar to 67-68 wt % after 28 day immersion in simulated body fluid confirmed that both composites can preserve their sterility overtime. (C) 2016 Elsevier Ltd. All rights reserved.