• 文献标题:   A hyaluronic acid/graphene oxide hydrogel for enhanced ex vivo expansion of cord blood-derived CD34(+) cells
  • 文献类型:   Article
  • 作  者:   GUO WZ, PAN XW, ZHANG YH, CAI HB, ZHANG WA
  • 作者关键词:   biomaterial, polymer, graphene oxide, stem cell, ex vivo expansion
  • 出版物名称:   MATERIALS LETTERS
  • ISSN:   0167-577X EI 1873-4979
  • 通讯作者地址:   East China Univ Sci Technol
  • 被引频次:   2
  • DOI:   10.1016/j.matlet.2017.06.023
  • 出版年:   2017

▎ 摘  要

HA/GO hydrogels were prepared by methacrylated GO (MeGO) and methacrylated HA (MeHA) via an in-situ free radical polymerization, and then a series of HA/GO hydrogels with highly porous structure were obtained. All hydrogels exhibited excellent water absorption ability. Additionally, the elastic moduli of hydrogels were clearly enhanced by GO. CD34(+) cells cultured on HA/GO-0.05 hydrogel showed higher expansion of CD34(+) cells and CD34(+) CD38(-) cells compared to the other three hydrogels. Therefore, HA/GO-0.05 hydrogels have a potential for clinical-applied ex vivo expansion of hematopoietic stem cells. (C) 2017 Elsevier B.V. All rights reserved.