▎ 摘　　要

Fabrication of selective, sensitive and reliable sensing platform for detection of propranolol (PRO) is still a great challenge. In this study, a new sensitive and selective electrochemical sensor was fabricated for the electrochemical determination of PRO using HgS/graphene composite. The incorporation of HgS microstructures on graphene sheets was done via a facile one-step method, where the simultaneous reduction of GO and the in-situ generation of HgS happened. Owing to the large surface area, excellent electronic conductivity and more electro-active sites provided by graphene, the HgS/graphene composite exhibited better electrochemical ability through the detection of PRO compared to the bare HgS. The HgS/graphene sensor revealed superb selectivity, good repeatability and superior stability of about 96.0 % of its original response after five weeks. Moreover, the sensor displayed excellent analytical parameters such as linear range of 0.5-50.0 mu M with low detection limit of 0.05 mu M (S/N = 3) and good sensitivity (0.1851 mu A/mu M). Furthermore, the constructed sensor was applied for detection of PRO in real and pharmaceutical samples, with good recoveries, ranging from 96.0 to 102.0%. The HgS/graphene composite provided here displayed satisfactory electrochemical features may hold great potential to the improvement of electrochemical sensors and electronic devices. (C) 2020 Elsevier B.V. All rights reserved.