• 文献标题:   A ternary CdS@Au-g-C3N4 heterojunction-based photoelectrochemical immunosensor for prostate specific antigen detection using graphene oxide-CuS as tags for signal amplification
  • 文献类型:   Article
  • 作  者:   CAO JT, DONG YX, MA Y, WANG B, MA SH, LIU YM
  • 作者关键词:   ternary cds@augc3n4 heterojunction, photoelectrochemical bioanalysi, graphene oxidecus, prostate specific antigen
  • 出版物名称:   ANALYTICA CHIMICA ACTA
  • ISSN:   0003-2670 EI 1873-4324
  • 通讯作者地址:   Xinyang Normal Univ
  • 被引频次:   3
  • DOI:   10.1016/j.aca.2020.01.067
  • 出版年:   2020

▎ 摘  要

Photoactive materials with high photo-electron transfer efficiency and stable signal output hold a key role in constructing the photoelectrochemical (PEC) biosensing systems. In this study, the ternary CdS@Au-g-C3N4 heterojunction was first prepared and characterized, and its application in PEC bioanalysis was explored. The gold nanoparticles sandwiched between CdS and g-C3N4, acting as both plasmonic photosensitizer and electron relay, significantly boosted the light absorption and accelerated the charge transfer from g-C3N4 to CdS, both of which contributed to the enhancement of photoelectric conversion efficiency. Signal quenching with graphene oxide-CuS efficiently weakened the photocurrent from CdS@Au-g-C3N4. The combination of the excellent PEC properties of CdS@Au-g-C3N4 and the remarkable quenching effects of graphene oxide-CuS enabled construction of a sandwich-type PEC immunosensor for prostate specific antigen (PSA) detection. This immunosensor achieved sensitive PSA analysis by multiple signal amplification mechanisms, with a detection limit of 0.6 pg mL(-1) and a wide linear range from 1.0 pg mL(-1) to 10 ng mL(-1). This work not only demonstrates the great potential of noble metal sandwiched ternary heterojunctions in the PEC field, but also lays a foundation for developing the general PEC immunoassays. (C) 2020 Published by Elsevier B.V.