▎ 摘　　要

Levodopa (l-dopa) is a gold standard neurologicaldrugfor symptomatic medication of Parkinson's disease. The long-termuse of l-dopa therapy frequently leads to l-dopa-induceddyskinesia and several other non-motor flocculants for fluctuatingplasma concentration. To alleviate the adverse effect of dopaminereplacement therapy, sensitive detection of l-dopa is stillchallenging. Therefore, this study presents a simple strategy to developan inexpensive, easy-to-use, smartphone-based fluorescence turn-onsensory system based on the aggregation-induced emission enhancementphenomenon for instant low-level detection of l-dopa in biologicalsamples. The sensor was fabricated using silk-fibroin-decorated reducedgraphene oxide quantum dots, which exhibit a progressive increaseof fluorescence intensity in the presence of l-dopa. By measuringthe turn-on efficiency of the sensor in elevated concentrations of l-dopa, the limit of detection (LOD) was evaluated as 76.18nM over a linear range of 0-35 mu M. We have further designeda smartphone-based electronic device involving a 365 nm light emittingdiode attached below the rare camera for capturing the change of fluorescentcolor of the solution during sensing. From these images, red, green,and blue values are analyzed using a mobile phone application, andthe corresponding LOD was found to be 0.29 mu M in a similar linearrange of concentration. This simple, cost-effective, and rapid screeninggadget is very demanding for on-spot detection of the analytes inremote areas where sophisticated instrumentation is not usually available.