▎ 摘　　要

Molecularly imprinted polymers with graphene oxide (GO) as a carrier (GMIPs) were synthesized to selectively recognize and capture cancer antigen 153 (CA153). The results show that the MIP has good selectivity and adsorption for CA153, and has strong anti-interference ability. Molecularly imprinted solid phase extraction (MISPE) combined with ultra performance liquid chromatography (UPLC) for the specific adsorption of CA153 was also established, and showed great potential for the analysis of CA153 in clinics in the future.