• 文献标题:   Synthesis of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones catalyzed by graphene oxide nanosheets in an aqueous medium: "on-water" synthesis accompanied by carbocatalysis and selective C-C bond cleavage
  • 文献类型:   Article
  • 作  者:   KAUSAR N, ROY I, CHATTOPADHYAY D, DAS AR
  • 作者关键词:  
  • 出版物名称:   RSC ADVANCES
  • ISSN:   2046-2069
  • 通讯作者地址:   Univ Calcutta
  • 被引频次:   32
  • DOI:   10.1039/c6ra00388e
  • 出版年:   2016

▎ 摘  要

Graphene oxide (GO) nanosheet catalyzed new and straightforward strategies for the construction of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones starting from anthranilamide (2-aminobenzamide) and an aldehyde/ketone in aqueous medium at room temperature have been realized. This catalyst is also found to be efficient for the expedient construction of quinazolin-4(3H)-ones starting from anthranilamide and a beta-ketoester/1,3-diketone following selective C-C bond cleavage of the beta-ketoester/1,3-diketone at an elevated temperature under metal and oxidant free conditions.